I don't know about you guys, but I definitely think that GTA was the right choice. Sure, MGS4 and LittleBigPlanet were great, but GTA pushed boundaries not only for technology, but for narrative as well. Every game on that list is fantastic, but GTA definitely deserves the award IMO.
Oh nevermind, it looks like Folding@home still runs with Life With PlayStation. Cool.
Why is Folding@home being replaced? It was a really nice little project, and PS3 seemed to have quite an impact.
No, the economy's to blame.