SuperGen says, "Prey is a game that almost didn’t exist. The original released back in 2006 after eleven full years of on-again, off-again type of development cycles. After such a long period, it was surprisingly good! Naturally, fans of the game wanted more, and it wasn’t long before we started seeing glimpses of Prey 2. Then in 2009, Bethesda acquired the rights to the franchise, and things start to get a little rocky. After many delays, a potential cancellation and then a changing-of-minds, the latest title in the series was finally handed off to Arkane Studios. Known for their work on the Dishonored series, the studio and Bethesda decided it would be best to start from ground zero, and re-imagine the series in a new light. Thus, the second installment in the series is simply called Prey, and it feels very much like an extension of everything Arkane has ever worked on."
Development footage of the canceled sequel to Bethesda Softworks and Human Head Studios' Prey has leaked online.

WolfEye Studios president and co-founder of Arkane Studios Raphaël Colantonio has said Dishonored and Prey fans “will be happy” with his new studio's next game.
Ouch, already placing a sales cap on this is potentially bad as these games never seem to sell all too well. Hopefully the budget is in check so no one gets laid off after launch.
Fuck yeah. Even if it’s just a spiritual successor I want more titles like Dishonored in terms of art style, design and gameplay

The magnificent Prey was once again abandoned as Microsoft disregarded Arkane Austin's achievements and crucified it just for Redfall.
well, not entirely ... the main Arkane studio i.e Arkane Lyon's still there ...
Its only that, the sequel will take more time now ... after Blade & Dishonored 3
Not even this Prey
Still longing for a sequel to the original Prey with Tommy
The studio didn't even want to call this Prey, it was just Bethesda being dicks to them for some reason.
Keep dreaming then as Prey and Dishonored 2 did not sell well enough to get sequels.
Hence we got Deathloop and Redfall instead.