It's going to be a while before we see the next installment in the Borderlands franchise. Until then Let's Predict what the next game will include.

The developers behind the original Borderlands discuss their last-second Hail Mary to change the course of the franchise.
ever since XIII came out I really loved the cell shaded artstyle in games. I probably wouldn't have tried it if it didn't have such a style like that

Take-Two: "We know there have been some concerns from Borderlands fans about Take-Two’s Terms of Service. Maintaining transparency and confidence with the community here is always our goal, and we wanted to address some of these concerns."

Nintendo Switch games that haven't received patches are still getting performance and loading boosts across the board on Switch 2.
I want the Original Vault Dwellers with their new upgrades shown off in the sequel. I mean you could do so much with the Liliths new powers
Just have to replace one of them
The franchise director left and they've put their resources into Battleborn. If BL3 or Borderworlds is ever going to happen, I can't see it being for a while.
Here's what I think would make an amazing Borderlands game. Instead of making it one planet with one vault, make the game take place in space with multiple planets. For example have the Hyperion base be the base of operations and you go to different planets, each with increasing difficulty. Have a map similar to the one in Destiny where you choose which planet to explore, and have 10-12 zones per planet. Then once you hit the higher levels there's a few planets you can choose from where you can grind out some gear. Borderlands 2 had a ton of zones, most of which you never go back to....so why not divvy those up over several planets? Then instead of making us wait several years for a sequel, they add a new planet once in a while, bump the level cap and make the new content challenging enough to keep people playing!