
1UP writes: " Inarguably the most massive survival horror franchise in gaming with a host of sequels, side stories, and even a trilogy of movies, the number in the title marks Resident Evil 5 as the next major chapter in the core story progression. Originally the series chronicled the Umbrella Corporation's attempt to create bio-engineered creatures for use as military weapons. Everything centered on the T-Virus, which, along with causing mutations, reanimated dead flesh, creating the game's legendary legions of zombies. The story took a major turn with Resident Evil 4, moving forward six years on the timeline to a fictional 2004, where Umbrella has gone bankrupt after having all its dealings exposed to the public. Leon Kennedy, who survived Resident Evil 2, found himself in rural Europe facing a cult of crazed villagers under the control of deranged leaders using mind-controlling parasites.
From early looks, Resident Evil 5 looks to continue on in this modern era of the story. As the latest trailer revealed (silencing arguments once and for all) the game takes place in Africa. Chris Redfield, who was one of the playable characters in the original Resident Evil and then took the lead in the second half of Code Veronica, once again takes the starring role in the fight. He now belongs to a mysterious organization known as BSAA and the game promises to answer at least some of the questions about what he's been doing over the past decade since the events in Raccoon City during the original game. This latest game also seems intent on continuing the more action-oriented style of play that defined Resident Evil 4."

Circana data shows Resident Evil 5 as the best selling Resident Evil game in the US, ahead of Resident Evil 4 remake and Village.
So the most successful RE is the one where a white man is killing Africans.
This can't be real.

New leaks from Dusk Golem detail cancelled Resident Evil projects, including a Rebecca focused Revelations game, while stating no Resident Evil 5 remake is in development.
Capcom's willingness to invest in experiments and scrap them sets them apart form many other developers (Nintendo have a similar methodology). Far too often companies push a game setting or game mechanic that is just not that good and the final product is middling or poor.

Dusk Golem claims a Resident Evil 5 remake is not coming this year, with a Code Veronica remake expected instead.
Hopefully if and when they do a RE5 remake, they give it the RE3 remake treatment, because this is certainly one title that I don't want a faithful remake of.